Prazepam


Concise Prescribing Info
Indications/Uses
Anxiety.
Dosage/Direction for Use
Adult : PO 30 mg/day as a single dose at night or in divided doses. Severe: ≤60 mg/day.
Dosage Details
Oral
Short-term management of anxiety
Adult: 30 mg daily as a single nightly dose or in divided doses, up to 60 mg daily in severe conditions.
Elderly: Initially, 10-15 mg daily.
Administration
May be taken with or without food.
Contraindications
Preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; chronic psychosis, phobic or obsessional states; glaucoma; porphyria. Myasthenia gravis.
Special Precautions
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy and lactation; history of alcohol or drug addiction due to risk of depression. resp depression and hypotension with parenteral admin, therefore this route should only be used when facilities for reversing resp depression are available. May precipitate suicide or aggressive behavior, not used alone to treat depression or anxiety associated with depression.
Adverse Reactions
Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia; rarely, jaundice, blood disorders and hypersensitivity reactions; pain and thrombophloebitis; raised liver enzyme values; paradoxical excitation.
Overdosage
Impairment of consciousness is quite rapid in overdosage.
Drug Interactions
Enhanced sedation or resp and CV depression with alcohol, drugs with CNS depressant properties eg, antidepressants, antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics and cisapride. Decreased serum levels when used with phenytoin. May increase the plasma levels of bupivacaine. Serum levels may be increased by valproate and modafinil.
Action
Description: Prazepam is a long-acting benzodiazepine with general properties similar to diazepam.
Pharmacokinetics:
Metabolism: Extensive first-pass metabolism in the liver.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Prazepam from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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