Prednisolone - oral

Patient Medicine Information
Why do I need this medicine?
Prednisolone is used to treat a wide variety of diseases such as allergic reactions and inflammatory conditions e.g. skin allergy, asthma, rheumatoid arthritis (inflammation of fingers, wrist, feet, ankles).

Prednisolone may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Prednisolone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine should be taken with food or milk to decrease stomach discomfort. Try to take it at the same time each day.

Prednisolone is available as a conventional or orally disintegrating tablet or as an oral solution.

If you are taking the orodispersible tablet:
  1. Remove it from the foil only just before you take it. Do not leave the orodispersible tablet exposed to air. Do not push the orodispersible tablet through the foil as it is fragile and easily broken.
  2. Remove the orodispersible tablet with dry hands by peeling the backing off the foil and tipping the tablet onto your dry hands.
  3. Place the orodispersible tablet directly on your tongue as soon as it is taken out of the foil. The orodispersible tablet will immediately start to melt on the tongue. It can then be swallowed with or without water.
Do not cut, break or crush the orodispersible tablets.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have an infection or if you have been vaccinated with a live vaccine, as Prednisolone may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • diabetes or family history of diabetes
  • glaucoma (increased pressure in the eye)
  • heart disease or high blood pressure
  • epilepsy (fits or seizures)
  • osteoporosis (brittle or weak bones)thyroid disease
  • myasthenia gravis (muscle weakness disorder)
  • blood clotting problems
  • systemic sclerosis (an autoimmune disorder characterized by thickening of the skin)
  • history of mental disorder after taking steroids
  • steroid myopathy (muscle weakness of the upper and lower limbs)
  • consistent eye infection
  • history of tuberculosis (lung infection)
  • kidney diseaseliver disease
  • stomach ulcer
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Prednisolone to a child.

Inform your doctor if you have been recently vaccinated.

Avoid exposure to anyone who is infected with chicken pox, shingles or measles. If you are expose to these infections, contact your doctor immediately.

For as long as you are taking this medicine, you may need to have regular blood tests to check your body’s response to the medicine. You may also need to have your eyes checked regularly. Your doctor will advise you about how often you need to have these tests.

Your doctor may also need to check the height of your children regularly.
What side effects could I experience?
Prednisolone may cause blurred vision. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: nausea, increased sweating, abdominal pain, weight gain, stomach ulcer, impaired healing, osteoporosis (brittle or weak bones), Cushingoid facies (swollen, round face), high blood pressure or heart disease, glaucoma (increased pressure in the eye), hirsutism (excessive body hair), and unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not receive live vaccines while you are taking Prednisolone.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for fits or seizures e.g. phenobarbital, carbamazepine, phenytoin, primidone, aminoglutethimide
  • medicines for diabetes e.g. insulin
  • medicines for pain and inflammation e.g. indomethacin, aspirin
  • blood thinning medicine e.g. warfarin
  • asthma medicine e.g. salbutamol, salmeterol, terbutaline, theophylline
  • rifampicin (medicine to treat TB)
  • water pills e.g. hydrochlorothiazide, furosemide, acetazolamide
  • ketoconazole (medicine to treat fungal infection)
  • troleandomycin (antibiotic)
  • ciclosporin (medicine used in organ transplant or certain immune disorders)
  • medicines for high blood pressure or heart disease e.g. metoprolol
  • mifepristone (medicine used for abortion)
  • medicines containing oestrogens e.g. birth control pills
This list does not include all medicines that may interact with Prednisolone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

The oral solution should be used within 1 month after opening.
This information is independently developed by MIMS based on prednisolone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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