HIGHLIGHT
Prevymis

Prevymis

letermovir

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Letermovir
Indications/Uses
Prophylaxis of cytomegalovirus (CMV) infection & disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT).
Dosage/Direction for Use
480 mg once daily started on transplant day & no later than 28 days post-transplant. Co-administration w/ cyclosporine Decreased to 240 mg once daily. Infusion conc: Administer by IV infusion over approx 60 min.
Administration
May be taken with or without food: Swallow whole, do not chew/crush/divide.
Contraindications
Hypersensitivity. Concomitant use w/ pimozide, ergot alkaloids; cyclosporine w/ pitavastatin o simvastatin.
Special Precautions
Monitor CVM DNA on wkly basis. Concomitant use w/ CYP3A substrates w/ narrow therapeutic ranges eg, alfentanil, fentanyl, quinidine. Not recommended in severe hepatic impairment; moderate hepatic impairment w/ moderate or severe renal impairment. End-stage renal disease w/ or w/o dialysis. Not recommended in women of childbearing potential & during pregnancy. Lactation. Childn <18 yr. Infusion conc: Not to be administered as IV bolus inj.
Adverse Reactions
Tachycardia, atrial fibrillation; nausea, diarrhoea, vomiting.
Drug Interactions
Decreased plasma conc by nafcillin, carbamazepine, phenobarb, phenytoin, rifabutin, rifampin, thioridazine, bosentan, St. John's wort, efavirenz, etravirine, nevirapine, modafinil. Decreased plasma conc of warfarin, voriconazole, proton-pump inhibitors. Increased plasma conc of amiodarone, glyburide, statins, HMG-CoA reductase inhibitors, cyclosporine, sirolimus, tacrolimus, CYP2C8 & CYP3A substrates.
MIMS Class
ATC Classification
J05AX18 - letermovir ; Belongs to the class of other antivirals. Used as a direct acting antiviral in the systemic treatment of viral infections.
Presentation/Packing
Form
Prevymis FC tab 240 mg
Packing/Price
28's
Form
Prevymis infusion conc (vial) 480 mg/24 mL
Packing/Price
1's
Form
Prevymis infusion conc (vial) 240 mg/12 mL
Packing/Price
1's
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