HIGHLIGHT
Prevymis

Prevymis Description

letermovir

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Full Prescribing Info
Description
Active Ingredient: PREVYMIS tablets contain 240 mg of letermovir.
PREVYMIS concentrate for solution for infusion is a clear, preservative-free sterile solution and may contain a few small translucent or white particles in single-dose vials of either 240 mg or 480 mg per vial. Each 1 mL of solution contains 20 mg letermovir.
Chemistry: Letermovir has a molecular formula of C29H28F4N4O4 and a molecular weight of 572.55. The chemical name for letermovir is (4S)-2-{8-Fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid. Letermovir is very slightly soluble in water.
Excipients/Inactive Ingredients: PREVYMIS tablets contain the following inactive ingredients: microcrystalline cellulose, croscarmellose sodium, povidone 25, colloidal silicon dioxide, magnesium stearate and film-coated with a coating material containing the following inactive ingredients: lactose monohydrate, hypromellose 2910, titanium dioxide, triacetin, and iron oxide yellow. Carnauba wax is added as a polishing agent.
Each 1 mL of PREVYMIS concentrate for solution for infusion contains the following inactive ingredients: hydroxypropyl betadex (150 mg), sodium chloride (3.1 mg), sodium hydroxide (1.2 mg), and Water for Injection. The amount of sodium hydroxide may be adjusted to achieve a pH of approximately 7.5.
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