Progesterone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Dysfunctional uterine bleeding, Amenorrhoea

Adult: 5-10 mg daily for 5-10 days until 2 days prior to expected onset of menstruation.

Intramuscular
Recurrent miscarriage with progesterone deficiency

Adult: 25-100 mg twice wkly from the 15^th day of pregnancy until 8-16 wk. May increase to daily inj, if necessary.

Intrauterine
Contraception

Adult: Insert the device (containing 38 mg of progesterone) into the uterine cavity; efficacy can last up till 1 yr.

Oral
Progestogen component of menopausal hormonal replacement therapy

Adult: 200 mg daily as a single daily dose at night for 12-14 days of each mth.

Oral
Amenorrhoea, Dysfunctional uterine bleeding

Adult: 400 mg daily for 10 days.

Vaginal
Premenstrual syndrome

Adult: 200 mg daily, may increase to 400 mg bid. Treatment is usually started on days 12-14 of the cycle and continues until onset of menstruation. Same doses may also be given rectally.

Vaginal
Dysfunctional uterine bleeding, Amenorrhoea

Adult: 45 mg every other day from the 15^th-25^th day of the cycle. May increase dose to 90 mg in non-responders.

Administration

Should be taken on an empty stomach.

Contraindications

Hypersensitivity; thrombophloebitis; cerebral apoplexy; severe hepatic impairment; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, as a diagnostic test for pregnancy; pregnancy. History or current high risk of arterial disease.

Special Precautions

Discontinue medications if there is sudden partial or complete loss of vision, proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asthma, cardiac or renal dysfunction. History of depression, glucose tolerance and diabetic patients. May impair ability to drive or operate machinery. Avoid sudden withdrawal of progesterone; lactation.

Adverse Reactions

GI disturbances, appetite/wt change, fluid retention, oedema, acne, skin rash, urticaria, depression, headache, fever, fatigue, breast changes, hirsutism, changes in libido, altered menstrual cycles or irregular menstrual bleeding (rare).

Pregnancy Category (US FDA)

PO: B

Drug Interactions

Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Ketoconazole may increase serum levels of progesterone. May inhibit ciclosporin metabolism.

Lab Interference

May alter serum lipid profile and rarely, LFTs.

Action

Description: Progesterone is the main hormone secreted by corpus luteum. It induces secretory changes in the endometrium, promotes mammary gland development, relaxes uterus, blocks follicular maturation and ovulation, and maintains pregnancy.
Pharmacokinetics:
Absorption: Oral bioavailability is low.
Distribution: Highly bound to plasma proteins. Distributes into breast milk.
Metabolism: Hepatic; extensive 1st-pass effect.
Excretion: Via the urine (as sulfate and glucuronide conjugates).

MIMS Class

Oestrogens, Progesterones & Related Synthetic Drugs

Disclaimer: This information is independently developed by MIMS based on Progesterone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com