Prostin E2

Prostin E2





Zuellig Pharma
Concise Prescribing Info
Induction of labour especially in patients w/ favourable induction features.
Dosage/Direction for Use
Initially, insert 1 tab high into posterior fornix. 2nd tab may be inserted after 6-8 hr if labor is not established. Max: 6 mg in 24 hr.
Hypersensitivity to dinoprostone or prostaglandins. History of caesarean section or major uterine surgery; cephalopelvic disproportion, fetal malpresentation is present; preexisting fetal distress; history of difficult labour &/or traumatic delivery; grand multiparae w/ >5 previous term pregnancies; unexplained vag discharge & bleeding &/or abnormal uterine bleeding; presence of ruptured membranes; placenta praevia. Patients w/ pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Asthma or history of asthma, epilepsy or history of epilepsy, glaucoma or raised IOP, compromised CV, hepatic or renal function, HTN, ruptured choriomniotic membranes; known history of hypertonic uterine contractility or tetanic uterine contractions; patients w/ compromised (scarred) uteri. Monitor uterine activity, fetal heart rate & cervical dilation during therapy. Evaluate cephalopelvic relationships prior to use. Women ≥35 yr & w/ gestational age >40 wk.
Adverse Reactions
Hypersensitivity reactions; diarrhea, nausea, vomiting; back pain; uterine contractile abnormalities & rupture, abruptio placenta, pulmonary amniotic fluid embolism, rapid cervical dilatation; warm feeling in vag; fever; HTN; asthma, bronchospasm; still births, neonatal death; fetal distress/altered fetal heart rate.
Drug Interactions
Accentuated response w/ exogenous prostaglandin therapy. Not recommended in concurrent use w/ other oxytocic agents.
MIMS Class
Drugs Acting on the Uterus
ATC Classification
G02AD02 - dinoprostone ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Prostin E2 vag tab 3 mg
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