Proxymetacaine


Concise Prescribing Info
Indications/Uses
Surface anaesthesia.
Dosage/Direction for Use
Adult : Ophth As 0.5% soln: Tonometry: Instil 1-2 drops before measurement. Removal of foreign body or suture: Instil 1-2 drops 2 or 3 min prior to procedure or every 5-10 min for 1-3 doses. Short corneal and conjunctival procedure: Instil 1 every 5-10 min for 5-7 doses.
Dosage Details
Ophthalmic
Surface anaesthesia
Adult: As 0.5% soln: For tonometry: Instil 1-2 drops immediately before measurement. For removal of foreign body or suture: Instil 1-2 drops 2 or 3 min prior to procedure or every 5-10 min for 1-3 doses. For short corneal and conjunctival procedure: Instil 1 drop every 5-10 min for 5-7 doses.
Child: Same as adult dose.
Contraindications
Preterm neonates.
Special Precautions
Patients w/ known allergies, cardiac disease, hyperthyroidism, inflamed eye. Prolonged use. Pregnancy and lactation.
Adverse Reactions
Significant: Permanent corneal opacification w/ vision loss (prolonged use).
Ophthalmologic: Burning sensation, redness, cycloplegia, mydriasis, stinging, conjunctival hemorrhage or hyperaemia, corneal erosion. Rarely, hyperallergic corneal reaction (e.g. acute, intense and diffuse epithelial keratitis; a grey ground-glass appearance; exfoliation of skin; corneal filaments, iritis w/ descemetitis).
Dermatologic: Allergic contact dermatitis.
Patient Counseling Information
This drug may cause transient blurring of vision, if affected, do not drive or operate machinery. Avoid touching or rubbing of eye(s) until anaesthesia has worn off.
Action
Description: Proxymetacaine, a meta-aminobenzoic acid ester, decreases Na ion permeability by reversibly blocking the initiation and conduction of impulse at the nerve cell membrane.
Onset: W/in 20 seconds.
Duration: Approx 10-20 min.
Pharmacokinetics:
Absorption: Readily absorbed into the systemic circulation.
Metabolism: Undergoes hydrolysis by plasma esterases; also subject to hepatic metabolism.
Chemical Structure

Chemical Structure Image
Proxymetacaine

Source: National Center for Biotechnology Information. PubChem Database. Proparacaine, CID=4935, https://pubchem.ncbi.nlm.nih.gov/compound/Proparacaine (accessed on Jan. 23, 2020)

Storage
Store between 2-8°C. Do not freeze. Protect from light.
ATC Classification
S01HA04 - proxymetacaine ; Belongs to the class of local ophthalmologic anesthetics.
References
Anon. Proparacaine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/04/2017 .

Buckingham R (ed). Proxymetacaine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/04/2017 .

Joint Formulary Committee. Proxymetacaine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/04/2017 .

McEvoy GK, Snow EK, Miller J et al (eds). Proparacaine Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/04/2017 .

Proparacaine Hydrochloride Solution/Drops (Sandoz Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/04/2017 .

Disclaimer: This information is independently developed by MIMS based on Proxymetacaine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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