Concise Prescribing Info
Ciprofloxacin HCl
Resp tract, middle ear, paranasal sinuses, eyes, kidneys &/or efferent urinary tract, biliary tract, GI, skin & soft tissues, bones & joints infection due to sensitive organisms. Peritonitis. Reduction of disease following exposure to aerosolised Bacillus anthracis. Bronchopulmonary infections of cystic fibrosis associated w/ Pseudomonas aeruginosa in childn 5-17 yr. 2nd- & 3rd-line treatment of complicated UTI & pyelonephritis due to E coli in childn 1-17 yr.
Dosage/Direction for Use
Resp tract infection & complicated UTI 250-500 mg bd. Acute & uncomplicated UTI 125-250 mg bd. Cystitis in women, acute & uncomplicated gonorrhea 250 mg single dose. Extragenital gonorrhea 125 mg bd. Diarrhea, post-exposure inhalational anthrax, other infections 500 mg bd. Strep pneumonia, recurrent infections in cystic fibrosis, bone & joint infections, septicemia, peritonitis 750 mg bd.
May be taken with or without food: May be taken w/ meals to minimize GI discomfort. Do not take w/ antacids, Fe or dairy products.
Hypersensitivity to ciprofloxacin or quinolones.
Special Precautions
Avoid use in patients w/ fluoroquinolone hypersensitivity & known history of myasthenia gravis. History of aneurysm disease, preexisting aortic aneurysm &/or aortic dissection, risk factors or conditions predisposing for aortic aneurysm & dissection (eg, Marfan syndrome, vascular Ehlers-Danlos syndrome, Takayasu arteritis, giant cell arteritis, Behcet's disease, HTN, known atherosclerosis). Increased risk of tendinitis & tendon rupture. Patients w/ solid organ transplants. Sensory or sensorimotor polyneuropathy. Avoid urine alkalinity. Ensure adequate hydration. Concomitant use w/ corticosteroids. May affect ability to drive & use machines. Renal impairment. Avoid use during pregnancy. Not to be used during lactation. Elderly >60 yr.
Adverse Reactions
Headache, abdominal pain/discomfort, foot pain, pain, pain in extremities; palpitation, atrial flutter, ventricular ectopy, syncope, HTN, angina pectoris, MI, cardiopulmonary arrest, cerebral thrombosis, phlebitis, tachycardia, migraine, hypotension; CNS events; psychiatric disorders; GI disturbances; lymphadenopathy, petechia; increased amylase & lipase; arthralgia or back pain, joint stiffness, achiness, neck or chest pain, gout flare up; renal/urogenital, resp or hypersensitivity reactions; blurred or disturbed vision, decreased visual acuity, diplopia, eye pain, tinnitus, hearing loss, chromatopsia.
Drug Interactions
Elevated serum conc of theophylline. Interfered w/ caffeine metabolism. Decreased absorption w/ multivalent cation-containing products eg, Mg/Al antacids, sucralfate, didanosine chewable/buffered tab or ped powd, other highly buffered drugs, Ca-, Fe- or Zn-containing products. Altered serum levels of phenytoin. Severe hypoglycemia w/ glyburide. Transient elevations in serum creatinine w/ cyclosporine. Enhanced effects of oral anticoagulants eg, warfarin. Interfered renal tubular secretion w/ probenecid. Increased plasma levels of methotrexate. Accelerated absorption w/ metoclopramide. Provoked convulsions w/ NSAIDs.
MIMS Class
ATC Classification
J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Pycip FC tab 500 mg
10 × 10's
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