Pyridoxine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Treatment and prevention of vit B6 deficiency Up to 150 mg/day Sideroblastic anaemia Up to 400 mg/day.
Dosage Details
Oral
Treatment and prophylaxis of vitamin B6 deficiency states
Adult: Up to 150 mg daily. May also be given via SC, IM or IV routes.

Oral
Sideroblastic anaemia
Adult: Up to 400 mg daily. May also be given via SC, IM or IV routes.
Administration
Should be taken with food.
Adverse Reactions
Severe peripheral neuropathies (with long-term admin of large doses).
IV/Parenteral/PO: A
Drug Interactions
Isoniazid, penicillamine and oral contraceptives may result in greater requirement in pyridoxine dose. Reduces the effects of levodopa, phenobarbitone, altretamine and phenytoin.
Lab Interference
May result in false-positive results for urobilinogen in the spot test using Ehrlich's reagent.
Action
Description: Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Pharmacokinetics:
Absorption: Well-absorbed from the GI tract following oral admin.
Distribution: Crosses the placenta and enters breast milk.
Metabolism: Converted to pyridoxal phosphate and pyridoxamine phosphate, which are stored and metabolised mainly in the liver.
Excretion: 4-pyridoxic acid and other active metabolites are excreted via the urine.
Disclaimer: This information is independently developed by MIMS based on Pyridoxine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Upha B6
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