Reminyl Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Galantamine HBr

Indications/Uses

Mild to moderately severe dementia of the Alzheimer type.

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Dosage/Direction for Use

Recommended starting dose: 8 mg daily for 4 wk. Maintenance dose: Initially 16 mg daily for at least 4 wk, may be increased to max: 24 mg daily if required. Patient w/ moderate hepatic impairment (Child-Pugh 7-9) Start w/ 8 mg every other day for at least 1 wk, followed by 8 mg once daily for at least 4 wk. Max: Not >16 mg daily.

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Overdosage

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Administration

Should be taken with food.

Contraindications

Hypersensitivity.

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Special Precautions

Discontinue use at the 1st appearance of rash. Not to be used for mild cognitive impairment. CV conditions eg, sick sinus syndrome or other supraventricular cardiac conduction disturbances, patients on drugs that significantly reduce heart rate eg, digoxin & β-blockers; history of ulcer disease or predisposing conditions. Not recommended in patients w/ GI obstruction or recovering from GI surgery. Convulsions; history of severe asthma or obstructive pulmonary disease. Urinary outflow obstruction or recovering from bladder surgery. Monitor patient's wt during therapy. Concurrent NSAIDs use. May affect ability to drive & use machines. Moderate to severe renal impairment. Not recommended in patients w/ CrCl <9 mL/min & severe hepatic impairment (Child-Pugh >9). Pregnancy. Not to be used during lactation. Not recommended in childn.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hallucination; HTN; nausea, vomiting, diarrhea; decreased appetite; headache, dizziness.

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Drug Interactions

Increased AUC w/ ketoconazole, paroxetine & erythromycin. Decreased clearance by amitriptyline, fluoxetine, fluvoxamine, paroxetine & quinidine. Increased cholinergic side effects w/ potent CYP2D6 or CYP3A4 inhibitors. Antagonised effect of anticholinergic medication. Exaggerated succinylcholine-type muscle relaxation during anaesth.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Reminyl detailed prescribing information

Storage

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Description

View Reminyl description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DA04 - galantamine ; Belongs to the class of anticholinesterases. Used in the management of dementia.

Regulatory Classification

Presentation/Packing

Form

Reminyl PR cap 16 mg

Packing/Price

28's

Form

Reminyl PR cap 8 mg

Packing/Price

28's

Reminyl

galantamine

Manufacturer:

Janssen

Distributor:

Zuellig Pharma