Discontinue use at the 1st appearance of rash. Not to be used for mild cognitive impairment. CV conditions eg, sick sinus syndrome or other supraventricular cardiac conduction disturbances, patients on drugs that significantly reduce heart rate eg, digoxin & β-blockers; history of ulcer disease or predisposing conditions. Not recommended in patients w/ GI obstruction or recovering from GI surgery. Convulsions; history of severe asthma or obstructive pulmonary disease. Urinary outflow obstruction or recovering from bladder surgery. Monitor patient's wt during therapy. Concurrent NSAIDs use. May affect ability to drive & use machines. Moderate to severe renal impairment. Not recommended in patients w/ CrCl <9 mL/min & severe hepatic impairment (Child-Pugh >9). Pregnancy. Not to be used during lactation. Not recommended in childn.