Requip PD 24 Hour

Requip PD 24 Hour

ropinirole

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Ropinirole HCl
Indications/Uses
Idiopathic Parkinson's disease. Monotherapy or in combination w/ l-dopa to control "on-off" fluctuations & reduce the total daily dose of l-dopa.
Dosage/Direction for Use
Adult Initially 2 mg once daily for 1st wk, increased to 4 mg once daily from 2nd wk. May be increased by 2 mg at wkly or longer intervals up to 8 mg once daily & may be further increased by 2-4 mg at 2-wkly or longer intervals. Max: 24 mg daily. Patient w/ end-stage renal disease (patient on haemodialysis) Initially 2 mg once daily. Max: 18 mg daily.
Administration
May be taken with or without food: Take at the same time each day. Swallow whole, do not chew/crush/divide.
Special Precautions
Severe CV disease, history or presence of major psychotic disorders. Monitor for impulse control disorders development. Avoid abrupt discontinuation. Allergic reactions due to azo colouring agent. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Not recommended in hepatic impairment. Severe renal impairment, end-stage renal disease. Not to be used during pregnancy & lactation. Not recommended in childn & adolescents <18 yr. Elderly ≥75 yr.
Adverse Reactions
Somnolence, syncope, dyskinesia; nausea, vomiting; peripheral oedema. Hallucinations, confusion, nervousness; dizziness (including vertigo), sudden sleep onset; postural hypotension, hypotension; abdominal pain, dyspepsia, constipation; fatigue.
Drug Interactions
Diminished effectiveness by sulpiride or metoclopramide. Increase Cmax & AUC by ciprofloxacin, enoxacin or fluvoxamine. Increased plasma conc w/ high-dose oestrogens. Induced CYP1A2 metabolism by smoking. Caution w/ alcohol.
ATC Classification
N04BC04 - ropinirole ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.
Presentation/Packing
Form
Requip PD 24 Hour PR tab 2 mg
Packing/Price
28's
Form
Requip PD 24 Hour PR tab 4 mg
Packing/Price
28's
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