Decreased metabolism rate by atovaquone. Reduced absorption by clarithromycin. Increased Cmax
w/ lamivudine. Lowered phenytoin blood levels. Increased mean t½
& AUC by probenecid. Decreased AUC w/ rifampicin. Inhibited intracellular phosphorylation of stavudine. Altered metabolism by aspirin, codeine, morphine, methadone, indomethacin, ketoprofen, naproxen, oxazepam, lorazepam, cimetidine, clofibrate, dapsone & isoprinosine. Increased risk of adverse reactions w/ potentially nephrotoxic or myelosuppressive drugs.