No specific information is available on the treatment of overdose with REXULTI. Gastric lavage and treatment with an emetic may be useful immediately after overdose. An electrocardiogram should be obtained in case of overdosage and if QT interval prolongation is present, cardiac monitoring should be instituted. Otherwise, management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers.
Consult a certified POISON CONTROL CENTER for up to date guidance and advice.
Oral activated charcoal and sorbitol (50 g/240 mL), administered one hour after ingesting oral brexpiprazole, decreased brexpiprazole Cmax and AUC by approximately 5% to 23% and 31% to 39% respectively; however, there is insufficient information available on the therapeutic potential of activated charcoal in treating an overdose with brexpiprazole. Although there is no information on the effect of hemodialysis in treating an overdose with REXULTI, hemodialysis is unlikely to be useful in overdose management since brexpiprazole is highly bound to plasma proteins.