Ritalin

Ritalin

methylphenidate

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Methylphenidate HCl
Indications/Uses
Dosage/Direction for Use
Adult Narcolepsy 20-30 mg daily. Max: 60 mg daily. Childn & adolescent ≥6 yr ADHD Initially 5 mg once or bd w/ 5 or 10 mg gradual wkly increments. Max: 60 mg daily.
Administration
May be taken with or without food: Take consistently either always w/ or always w/o food.
Contraindications
Hypersensitivity. Anxiety, tension; agitation; hyperthyroidism; preexisting CV disorders including severe HTN, angina, arterial occlusive disease, heart failure, congenital heart disease, cardiomyopathies, MI, arrhythmias & channelopathies; glaucoma; phaeochromocytoma. Diagnosis or family history of Tourette's syndrome. Concomitant use w/ MAOIs or w/in min of 2 wk discontinuation.
Special Precautions
Discontinue use if seizure frequency increases. Not to be used in patients w/ structural cardiac abnormalities or other serious cardiac disorders; preexisting CNS abnormalities eg, cerebral aneurysm &/or other vascular abnormalities eg, vasculitis or preexisting stroke. Not to be initiated in patients w/ acute psychosis, mania or suicidality; emergent psychiatric symptoms (eg, hallucinations or mania, aggressive behaviour & suicidal tendency) or exacerbation of preexisting symptoms. Conditions compromised by increased BP or heart rate eg, preexisting HTN; priapism; emotionally unstable patients eg, history of drug dependence or alcoholism. Marked tolerance & psychological dependence. Avoid abrupt w/drawal. Periodically monitor & perform complete & differential blood & platelet count during long-term therapy. Monitor for clinical worsening, suicidal thoughts & unusual changed behaviour. Assess for preexisting CV & psychiatric disorders, family history of sudden death, ventricular arrhythmia & psychiatric disorders & measure wt & height prior to treatment; family history & clinical evaluation for Tourette's syndrome. Regularly monitor for emergence or worsening of tics & growth development during treatment. Not recommended to be used w/ serotonergic drugs. Concomitant use w/ BP-elevating medications. May affect ability to drive & use machines. Not to be given during pregnancy. Lactation. Not to be used in childn <6 yr.
Adverse Reactions
Nasopharyngitis; decreased appetite; nervousness, insomnia; nausea, dry mouth. Anxiety, restlessness, sleep disorder, agitation, depression, aggression, bruxism; dyskinesia, tremor, headache, drowsiness, dizziness; tachycardia, palpitation, arrhythmias, BP & heart rate changes; cough; abdominal pain, vomiting, dyspepsia, toothache; rash, pruritus, urticaria, fever, scalp hair loss, hyperhidrosis; arthralgia; feeling jittery; decreased wt; Raynaud's phenomenon, peripheral coldness.
Drug Interactions
Decreased effectiveness of antihypertensives. Possible hypertensive crisis w/ MAOIs. Exacerbated adverse CNS effects w/ alcohol. Increased BP & heart rate w/ anesth. Serious adverse events eg, sudden death w/ centrally-acting α2-agonists eg, clonidine. Development of serotonin syndrome w/ serotonergic drugs. Pharmacodynamic interactions w/ direct & indirect dopamine agonists (eg, DOPA, TCAs, antipsychotics). Counteracted mechanism of action w/ antipsychotics. Induced false-positive laboratory tests for amphetamines. Potential interaction w/ coumarin anticoagulants, anticonvulsants (eg, phenobarb, phenytoin, primidone), phenylbutazone. BP-elevating drugs.
MIMS Class
Other CNS Drugs & Agents for ADHD
ATC Classification
N06BA04 - methylphenidate ; Belongs to the class of centrally-acting sympathomimetics. Used as CNS stimulant.
Presentation/Packing
Form
Ritalin IR tab 10 mg
Packing/Price
100's;200's;30's
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