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Rocephin

Rocephin

ceftriaxone

Manufacturer:

Roche

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Ceftriaxone
Indications/Uses
Sepsis; meningitis; early & late disseminated Lyme borreliosis; abdominal infections (peritonitis, biliary & GI tract infection); bones, joints, soft tissue, skin, wound & renal infections; infections in patients w/ impaired defense mechanisms; UTI; resp tract infections particularly pneumonia; ear, nose & throat infections; genital infections including gonorrhea; peri-op prophylaxis of infections.
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Dosage/Direction for Use
Adult & childn >12 yr 1-2 g once daily. Severe infection May be increased up to 4 g once daily. Neonate, infant & childn (15 days-12 yr) 20-80 mg/kg once daily. Neonate up to 14 days 20-50 mg/kg once daily, not to exceed 50 mg/kg. Meningitis Infant & childn Initially 100 mg/kg once daily. Max: 4 g once daily. Lyme borreliosis Adult & childn 50 mg/kg once daily for 14 days. Max: 2 g daily. Gonorrhea 250 mg single IM dose. Peri-op prophylaxis 1-2 g single dose 30-90 min pre-op.
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Overdosage
View Rocephin overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to lidocaine, ceftriaxone or other cephalosporins, penicillin or other β-lactams. Neonate ≤28 days on treatment w/ Ca-containing IV soln. Hyperbilirubinemic newborns, premature neonates up to 41 wk postmenstrual age.
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Special Precautions
Discontinue use in case of severe hypersensitivity; history of hypersensitivity to ceftriaxone, other cephalosporins or other β-lactams. Immune-mediated hemolytic anemia. Clostridium difficile-associated diarrhea. Superinfections. Pancreatitis. Monitor CBC during prolonged treatment. False +ve Coombs' test. Not to be mixed or administered w/ Ca-containing soln or products. May affect ability to drive & use machines. Severe renal & hepatic dysfunction. Pregnancy & lactation. Not to be used in neonates at risk of developing bilirubin encephalopathy.
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Adverse Reactions
Eosinophilia, leucopenia, thrombocytopenia; diarrhoea, loose stools; increased hepatic enzyme; rash.
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Drug Interactions
Antagonistic effects w/ chloramphenicol. Precipitation w/ Ca-containing diluents eg, Ringer's or Hartmann's soln. Increased risk of bleeding w/ vit K antagonists. Chemical incompatibility w/ IV amsacrine, vancomycin, fluconazole, aminoglycosides.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Rocephin detailed prescribing information
Storage
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Description
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Action
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MIMS Class
Cephalosporins
ATC Classification
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Rocephin powd for IM/IV inj 1 g
Packing/Price
1's
Form
Rocephin powd for IM/IV inj 250 mg
Packing/Price
1's
Form
Rocephin powd for IM/IV inj 500 mg
Packing/Price
1's
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