Discontinue use if interstitial lung disease develops & creatine kinase >5 times ULN occurs. Not to be used in patients w/ acute, serious condition of myopathy or predisposing to renal failure development secondary to rhabdomyolysis eg, sepsis, hypotension, major surgery, trauma, severe metabolic, endocrine & electrolyte disorders or uncontrolled seizures. Predisposing factors for myopathy/rhabdomyolysis eg, hypothyroidism, history of hereditary muscular disorders, history of muscular toxicity w/ another HMG-CoA reductase inhibitor or fibrate, conditions where increased plasma levels occur. Proteinuria; DM. Assess renal function during routine follow-up. Perform liver function test prior to & 3 mth following initiation. Excessive alcohol consumption. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be used w/ fusidic acid or w/in 7 days of discontinuation. Not recommended in combination w/ gemfibrozil; PIs. Concomitant use w/ fibrates, niacin. History of hepatic disease. Women of childbearing potential should use effective contraception. Not to be used during pregnancy & lactation. Childn <10 yr. Elderly >70 yr.