Interactions may occur if the following drugs are given at the same time as Salofalk.
Anticoagulants: Possible potentiation of the anticoagulative action (increased risk of bleeding in the gastrointestinal tract).
Glucocorticoids: Possible increase in gastric side effects.
Sulphonylureas: Possible potentiation of the hypoglycaemic effect.
Methotrexate: Possible increase of the methotrexate toxicity.
Probenecid/Sulphinpyrazone: Possible reduction in uricosuric effects.
Spironolactone/Furosemide: Possible reduction in diuretic effects.
Rifampicin: Possible reduction in tuberculostatic effects.
Pancytopaenia occurred in one case under mesalazine in combination with mercaptopurine.
Granules: Specific interaction studies have not been performed.
Lactulose or similar preparations which lower stool pH: possible reduction of mesalazine release from granules due to decreased pH caused by bacterial metabolism.
In patients who are concomitantly treated with azathioprine, 6-mercaptopurine or thioguanine, a possible increase in the myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine should be taken into account.
There is weak evidence that mesalazine might decrease the anticoagulant effect of warfarin.