TabCrohn's disease (acute attack) 1.5-4.5 g daily. Ulcerative colitis Acute attack: 1.5-3 g daily. Remission: 1.5 g daily. SuppUlcerative colitis Acute attack: 1.5 g daily. Remission: 0.75 g daily. Enema Administer 60 mL in the evening. GranulesUlcerative colitis Adult Acute attack: 1-2 sachets once daily in the morning. Remission: 0.5 g tds or 3 g as single daily dose in the morning. Childn Active disease: Individualized dosage, initially 30-50 mg/kg daily in the morning or in divided doses. Max dose: 75 mg/kg daily. Total dose: Not to exceed max adult dose. Maintenance: Individualized dosage, initially 15-30 mg/kg daily in divided doses. Total dose: Not to exceed max adult dose. Recommended dose: Childn up to 40 kg ½ adult dose, >40 kg Adult dose.
View Salofalk overdosage for action to be taken in the event of an overdose.
Administration
Should be taken on an empty stomach: Tab: Take 1 hr before meals. Swallow whole, do not chew/crush. PR granules: Place on the tongue w/o chewing. Swallow w/ plenty of liqd.
Contraindications
Hypersensitivity to mesalazine or salicylates. Active peptic ulcer; blood clotting abnormalities. Severe hepatic & renal impairment. Babies & infants.
Enhanced hypoglycemic effects of sulfonylureas. Coumarins, methotrexate, probenecid, sulfinpyrazone, furosemide, rifampicin. Granules: Possible reduction of release due to decreased pH caused by bacterial metabolism w/ lactulose or similar prep lowering stool pH. Possible increased myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine. Decreased anticoagulant effect of warfarin.
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