Avoid use w/ live attenuated vaccines. Increased serum K w/ K-sparing & -containing drugs. Increased AUC w/ lercanidipine. Decreased levels by barbiturates, carbamazepine, oxcarbazepine, phenytoin, nafcillin, sulfadimidine IV, rifampicin, octreotide, probucol, orlistat, Hypericum perforatum
(St. John's wort), ticlopidine, sulfinpyrazone, terbinafine, bosentan. Increased levels by macrolides, ketoconazole, fluconazole, itraconazole, voriconazole, diltiazem, nicardipine, verapamil, metoclopramide, OCs, danazol, methylprednisolone (high dose), allopurinol, amiodarone, cholic acid & derivatives, PIs, imatinib, nefazodone. Increased bioavailability w/ grapefruit juice. Potential increased nephrotoxicity w/ aminogylcosides, amphotericin B, ciprofloxacin, vancomycin, trimethoprim + sulfamethoxazole, NSAIDs (including diclofenac, naproxen, sulindac), melphalan, H2
-receptor antagonists, MTX, tacrolimus. Increased bioavailability of diclofenac. Reversible kidney impairment w/ fibric acid derivatives (eg, bezafibrate, fenofibrate). Increased rate of gingival hyperplasia w/ nifedipine. Increased plasma levels of CYP3A4 enzymes & P-gp transporters. Reduced clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), etoposide, aliskiren, bosentan, dabigatran. Increased blood levels of everolimus, sirolimus. Increased repaglinide plasma conc. Increased exposure of ambrisentan, anthracycline antibiotics eg, doxorubicine, mitoxanthrone, daunorubicine.