Pharmacology: (Summary of Pharmacodynamics and Pharmacokinetics): Silymarin is extracted from the seeds of the milk thistle (Silybum marianum Gaertn), a species known as an efficacious medicinal plant. A number of animal experiment were carried out and this drug was shown to protect liver damage from various hepatotoxic drugs. The therapeutic action of Silymarin is in stabilizing the liver cell membrane as well as the biomembranes of the organelles against toxic influences.
The vitamins of B-Complex are components of enzymes and participate as actual biocatalysts in many reaction cycles which occur in the liver cells. They accelerate the reparation of damaged liver parenchyma, and thus promote the organ's detoxifying action. Moreover, liver cells damaged through exogenous or endogenous toxins have a reduced accumulation capacity for vitamin B due to cell membranes no longer fully functioning. Therefore administration of the B-Complex vitamins can compensate such deficiencies.
Silymarin undergoes enterohepatic circulation and is mainly excreted via bile. Its major component, silybin, is excreted mainly by the kidney, although metabolites, particularly sulfate and glucuronide conjugates, are also present in bile. The total amount of silybin excreted in bile is about 20%-40% of the ingested dose. Only 3%-7% of the total dose is excreted renally.