Silymarin, vitamin B1, vitamin B2, vitamin B6, vitamin B3, vitamin B5.
Each capsule contains Silymarin 70 mg, Thiamine Mononitrate (Vitamin B1) 4 mg (e.q to Thiamine HCl), Riboflavin (Vitamin B2) 4 mg, Pyridoxine HCl (Vitamin B6) 4 mg, Nicotinamide (Vitamin B3) 12 mg, Calcium Panthothenate (Vitamin B5) 8 mg.
Pharmacology: (Summary of Pharmacodynamics and Pharmacokinetics): Silymarin is extracted from the seeds of the milk thistle (Silybum marianum Gaertn), a species known as an efficacious medicinal plant. A number of animal experiment were carried out and this drug was shown to protect liver damage from various hepatotoxic drugs. The therapeutic action of Silymarin is in stabilizing the liver cell membrane as well as the biomembranes of the organelles against toxic influences.
The vitamins of B-Complex are components of enzymes and participate as actual biocatalysts in many reaction cycles which occur in the liver cells. They accelerate the reparation of damaged liver parenchyma, and thus promote the organ's detoxifying action. Moreover, liver cells damaged through exogenous or endogenous toxins have a reduced accumulation capacity for vitamin B due to cell membranes no longer fully functioning. Therefore administration of the B-Complex vitamins can compensate such deficiencies.
Silymarin undergoes enterohepatic circulation and is mainly excreted via bile. Its major component, silybin, is excreted mainly by the kidney, although metabolites, particularly sulfate and glucuronide conjugates, are also present in bile. The total amount of silybin excreted in bile is about 20%-40% of the ingested dose. Only 3%-7% of the total dose is excreted renally.
As an adjuvant in the treatment of the following diseases such as chronic liver disease, liver cirrhosis, fatty liver and intoxication by hepatotoxic substance.
1-2 capsules depending on the severity of the case, three times daily after meal.
There is no specific antidote for its overdose. In case of overdosage, discontinue medication, treat symptomatically, and initiate supportive measures.
Contraindicated in patients hypersensitive to any of its components.
Problems have not been documented with intake of normal daily requirements. Studies have not been done in pregnant women, therefore Hepavite should be given to a pregnant woman only if clearly needed.
Silymarin and water-soluble vitamins seldom cause toxicity in persons with normal renal function.
Interactions with other drugs are not known.
Keep in a tight container. Store at temperature below 25°C. Protect from light and moisture.
Shelf-Life: 3 years from the date of manufacture.
A11AB - Multivitamins, other combinations ; Used as dietary supplements.
Cap (size #2 deep red cap and body, hard gelatin capsule) 2 x 10's, 10 x 10's, 100 x 10's.