Discontinue use if allergic reactions occur. Compromised corneas eg, patients w/ DM or corneal dystrophies. Severe CV disorders; depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. May cause eye irritation due to benzalkonium Cl. Avoid contact w/ soft contact lenses. Remove contant lens prior to application & wait 15 min before reinsertion. May affect ability to drive & use machines. Hepatic & severe renal impairment. Not recommended in childn & adolescents ≥2 yr.
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