Discontinue use if signs of serious reactions or hypersensitivity occur. Not recommended in narrow-angle glaucoma. Patients w/ compromised corneas eg, w/ DM or corneal dystrophies; low endothelial cell count; severe or unstable & uncontrolled CV disease; depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. May cause eye irritation due to benzalkonium Cl. Remove contact lens prior to application & wait 15 min before reinsertion. Prolonged use. Concomitant use w/ antihypertensives &/or cardiac glycosides. May affect ability to drive & use machines. Hepatic & severe renal impairment. Women of childbearing potential should use effective contraception. Not recommended during pregnancy. Not to be used during lactation. Not recommended in childn & adolescents ≥2 yr.