Sodium acetate


Concise Prescribing Info
Indications/Uses
As source of Na.
Dosage/Direction for Use
Adult : IV May be added to large vol IV fluids in patients w/ restricted or no oral intake. Adjust dose and rate of administration based on serum Na readings.
Dosage Details
Intravenous
Source of sodium
Adult: May be added to large volume IV fluids to prevent or correct hyponatraemia in patients with restricted or no oral intake. Dose and rate of administration depends on the needs of the patient. Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: 3-4 mEq/kg/24 hr or 25-40 mEq/1000 kcal/24 hr (Daily requirements), Maximum: 100-150 mEq/24 hr. Monitor serum sodium for dosage adjustments.
Elderly: Lower doses may be required.
Contraindications
Respiratory or metabolic alkalosis, hypocalcaemia, hyponatraemia, fluid retention.
Special Precautions
Renal failure, severe renal insufficiency and in clinical states where there is oedema with sodium retention, hepatic failure, heart failure, hypertension, eclampsia, aldosteronism. Avoid extravasation. Pregnancy.
Adverse Reactions
Thrombosis, hypervolaemia; chemical cellulitis at inj site (extravasation); hypernatraemia, dilution of serum electrolytes, over-hydration, hypokalaemia, metabolic alkalosis, hypocalcaemia; gastric distension, flatulence; phlebitis; pulmonary oedema; congestive conditions.
Overdosage
Discontinue treatment and initiate corrective measures to reduce increased sodium levels and restore acid-base balance.
Drug Interactions
May affect the absorption of certain drugs due to increased intra-gastric pH. May increase renal clearance of acidic drugs e.g. salicylates and barbiturates, and prolongs the half-life of basic drugs.
Action
Description: Sodium plays an important role in controlling the total body water and its distribution. Sodium is the main cation in the extracellular fluid and comprises >90% of total cations. The acetate component is an alternate source of bicarbonate by metabolic conversion in the liver.
Pharmacokinetics:
Metabolism: Occurs rapidly and completely into bicarbonate even in the presence of severe liver disease.
Storage
Store at 20-25°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Sodium acetate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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