Sodium fluoride


Concise Prescribing Info
Indications/Uses
Prophylaxis of dental caries.
Dosage/Direction for Use
Adult : PO Per loz contains 1 mg fluoride: 1 loz/day regardless of fluoride content of drinking water. Topical As 0.2% or 0.05% rinsing solutions: Rinse 10 mL once daily or wkly, preferably at bedtime after brushing the teeth. Rinse solution around and between teeth for 1 minute and spit after rinsing. As gel containing 1.1% sodium fluoride: Apply a thin layer of the gel to the teeth daily (preferably at bedtime after brushing the teeth) for at least 1 minute and spit after application.
Dosage Details
Oral
Prophylaxis of dental caries
Adult: Per loz contains 1 mg fluoride: 1 loz daily regardless of fluoride content of drinking water.
Child: Based on fluoride content of drinking water: Water-fluoride content <0.3 ppm: 6 mth-3 yr: 0.25 mg daily; 3-6 yr: 0.5 mg daily; >6 yr: 1 mg daily. Water-fluoride content 0.3-0.6 ppm: <3 yr: Not recommended; 3-6 yr: 0.25 mg daily; >6 yr: 0.5 mg daily. Tablets should be sucked or chewed before swallowing.

Topical/Cutaneous
Prophylaxis of dental caries
Adult: As 0.2% or 0.05% rinsing solutions: Rinse 10 mL once daily or wkly, preferably at bedtime after brushing the teeth. Rinse solution around and between teeth for 1 minute and spit after rinsing. As gel containing 1.1% sodium fluoride: Apply a thin layer of the gel to the teeth daily (preferably at bedtime after brushing the teeth) using a toothbrush or mouth tray for at least 1 minute and spit after application. For max benefit, do not eat, drink or rinse their mouth for at least 30 minutes after using the rinsing solution or dental gel.
Child: ≥6 yr: As 0.2% or 0.05% rinsing solutions: Rinse 10 mL once daily or wkly, preferably at bedtime after brushing the teeth. Rinse solution around and between teeth for 1 minute and spit after rinsing. As gel containing 1.1% sodium fluoride: Apply a thin layer of the gel to the teeth daily (preferably at bedtime after brushing the teeth) using a toothbrush or mouth tray for at least 1 minute and spit after application. Rinse the mouth thoroughly after spitting the gel.
Contraindications
Not to use 1 mg tablets in children <3 yr of age or when drinking water fluoride content is ≥0.3 ppm.
Special Precautions
Prolonged treatment with large amounts of fluoride may result in dental fluorosis and osseous changes; do not exceed recommended dosage. Renal impairment. Pregnancy.
Adverse Reactions
Hypersensitivity reactions, rash, nausea, vomiting. Products containing stannous fluoride may cause teeth staining.
Overdosage
In acute poisoning, symptoms include a salty or soapy taste, increased salivation, GI disturbances, abdominal pain, weakness, drowsiness, faintness and shallow breathing; more serious effects include hypocalcaemia, hypomagnesaemia, hyperkalaemia, tremors, convulsions, cardiac arrhythmias, shock, respiratory arrest and cardiac failure. Death may occur within 2-4 hr. Treatment includes gastric lavage with lime water or a weak solution of another calcium salt to precipitate fluoride. Maintain high urine output, slow IV inj of calcium gluconate 10% may be used for hypocalcaemia and tetany. Magnesium sulfate may be given to treat hypomagnesaemia, and aluminium hydroxide may help to reduce fluoride absorption. Haemodialysis may be considered. Chronic fluoride poisoning may cause skeletal fluorosis resulting in bone pain, stiffness, limited movment and in severe cases, crippling deformities. In children, prolonged excessive intake during tooth development before eruption may cause dental fluorosis characterised by mottled enamel.
Drug Interactions
Absorption of fluoride may be reduced by aluminium, calcium and magnesium salts.
Action
Description: Sodium fluoride is a cariostatic agent that is used to prevent dental caries. It can also be used as a source of fluoride in total parenteral nutrition.
Pharmacokinetics:
Absorption: Well-absorbed from the GI tract. Inhaled fluorides are absorbed through the lungs.
Distribution: Crosses the placenta and enters the breast milk. Deposited mainly in teeth and bones but also present in saliva, nails and hair.
Excretion: Mainly in the urine, with small amounts appearing in sweat and faeces.
Storage
Store in tight plastic containers.
Disclaimer: This information is independently developed by MIMS based on Sodium fluoride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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