Sofosbuvir + velpatasvir - oral

Patient Medicine Information
Why do I need this medicine?
Sofosbuvir and Velpatasvir are combined together in this medicine.

Sofosbuvir + Velpatasvir is used on its own or together with ribavirin to treat hepatitis C virus infection of the liver.
How do I take this medicine?
Take Sofosbuvir + Velpatasvir exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Swallow it whole with a glass of water. Do not divide, chew or crush the tablet.

Try to take it at the same time each day.

If you vomit less than 3 hours after taking Sofosbuvir + Velpatasvir, take another tablet. If you vomit more than 3 hours after taking this medicine, you do not need to take another tablet until your next scheduled dose.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your infection.

You must complete the entire course of medicine. If you don't, the infection will not be properly controlled.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is more than 18 hours since you missed the dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Sofosbuvir, Velpatasvir or any other similar medicines.

Do not take Sofosbuvir + Velpatasvir with ribavirin if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with these medicines, alert your doctor immediately. Ribavirin may cause harm to your unborn child. It is important that you do not get pregnant during the treatment. You must use proven birth control methods while taking Sofosbuvir + Velpatasvir with ribavirin. You may wish to discuss birth control methods with your doctor or pharmacist.

Do not take Sofosbuvir + Velpatasvir with medicines to treat an infection known as tuberculosis and epilepsy.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • current or previous hepatitis B virus infection of the liver
  • HIV infection
  • at risk of slow heartbeat
Let your doctor know if you are pregnant or breastfeeding.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • If you ever had hepatitis B virus infection, it could become active again during or after treatment of hepatitis C virus with Sofosbuvir + Velpatasvir. This may cause serious liver problems. Your doctor will check if you are at risk for hepatitis B virus reactivation.
  • You may need to have routine blood tests (e.g. complete blood count, liver function test). Your doctor will advise you about how often you will need to have these tests.
  • If you are pregnant, Sofosbuvir + Velpatasvir when taken with ribavirin may not be suitable for you. Pregnancy test may be done prior to initiation, during and 6 months after treatment.
  • Regular monitoring of heart rate may be needed if you are taking this medicine with amiodarone.
What side effects could I experience?
Sofosbuvir + Velpatasvir may cause any of the following: nausea, diarrhoea, irritability, headache, difficulty sleeping, tiredness, weakness, and cough.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of allergy e.g. breathlessness, swelling of the face, lips, or tongue, and rashes
  • signs of liver problems e.g. yellowing of the skin or eyes
  • chest pain
  • fainting or near fainting
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Sofosbuvir + Velpatasvir with the following medicines:
  • medicines to treat TB (an infection known as tuberculosis) e.g. rifampicin
  • medicines for epilepsy (fits or seizures) e.g. phenytoin, phenobarbital, carbamazepine
  • herbal medicine e.g. St. John’s wort
This medicine should not be taken with stomach medicines such as omeprazole, famotidine or antacids (medicines to neutralise stomach acid) as it could reduce the effectiveness of Sofosbuvir + Velpatasvir. Your doctor may give you a different medicine or adjust the dose of these medicines. Take it exactly as instructed by your doctor.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicine for irregular heartbeat e.g. amiodarone
  • other medicine for epilepsy e.g. oxcarbazepine
  • cholesterol-lowering medicine e.g. rosuvastatin
  • medicines for HIV infection e.g. tenofovir, efavirenz
  • medicine for heart disease e.g. digoxin
  • blood-thinning medicine e.g. warfarin
This list does not include all medicines that may interact with Sofosbuvir + Velpatasvir.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from light.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on sofosbuvir + velpatasvir - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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