Somatostatin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Intravenous
Gastrointestinal haemorrhage

Adult: Initially, 250 mcg as a bolus inj over 3-5 min, followed by a continuous infusion of 3.5 mcg/kg/hr until bleeding has ceased. May continue for a further 48-72 hr to prevent recurrent bleeding.

Special Precautions

Monitor blood glucose levels. May inhibit intestinal absorption thus concomitant parenteral nutrition may be recommended.

Adverse Reactions

Rapid infusion may lead to abdominal discomfort, nausea, flushing, bradycardia.

Action

Description: Somatostatin is a polypetide obtained synthetically or from the hypothalamus. It acts by inhibiting the release of growth hormone from the anterior pituitary. It also inhibits the release of thyrotrophin and corticotropin from the pituitary, glucagon and insulin from the pancreas. It also regulates duodenal and gastric secretions. It may also play a role in pain perception.

MIMS Class

Haemostatics / Trophic Hormones & Related Synthetic Drugs

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