Patients who have previously shown hypersensitivity to the drug. Patients with active peptic ulceration or a history of peptic ulceration; active gastrointestinal bleeding; ulcerative colitis, severe hepatic and/or renal impairment. Severe heart failure (NYHA III-IV). Since cross reactivity, between acetylsalicylic acid and other non-steroidal anti inflammatory drugs (NSAIDs) has been reported, SPEDIFEN is contraindicated in patients in whom aspirin and other NSAIDs induced allergic reactions such as asthma, urticaria, rhinitis, nasal polyps, angioedema. Patients with systemic lupus erythematosus and with collagen diseases must consult the physician before use SPEDIFEN.