Discontinue use if bronchospasm occurs. Not suitable for phenylketonurics. Serious skin reactions eg, Stevens-Johnson syndrome & Lyell's syndrome. History of peptic ulcer. Perform postural drainage & bronchoaspiration in patients unable to cough up secretions. Patients on Na-restricted diet. Avoid long-term therapy in patients w/ histamine intolerance. Renal or hepatic impairment. Pregnancy & lactation.
Inactivation of antibiotics. Lead to build-up of bronchial secretions w/ antitussive medicinal products. Increased vasodilatory & platelet aggregation-inhibiting effect of nitroglycerin. Decreased effect by activated charcoal. Affected values of salicylates by colorimetric analysis. Interfered w/ ketone tests in urine.