Amlodipine should be used with caution in patients with hypotension, cardiac reserve is poor, heart failure.
The drug should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina, in treatment an anginal attack in chronic stable angina.
In patients with severe aortic stenosis amlodipine may increase the risk of developing heart failure.
Sudden withdrawal of amlodipine might be associated with an exacerbation of angina.
The dose may need to be reduced in patients with hepatic impairment.
Effects on Ability to Drive and Use Machine: Amlodipine can have minor or moderate influence on the ability to drive and use machines. If patients taking amlodipine suffer from dizziness, headache, fatigue or nausea the ability to react may be impaired. Caution is recommended especially at the start of treatment.