Cryptococcal meningitis & other infections 400 mg on 1st day followed by 200-400 mg once daily for 6-8 wk. Prevention of Cryptococcal meningitis relapse in patient w/ AIDS 200 mg daily. Candidemia, disseminated candidiasis & other invasive Candida infections 400 mg on 1st day followed by 200 mg daily. Prevention of candidiasis 50-400 mg once daily. Patient at high risk systemic infection 400 mg once daily. Systemic candidiasis & cyptococcal infections 6-12 mg/kg daily. Patient w/ renal impairment Initial dose: 50-400 mg. Adjust dose according to CrCl: >50 mL/min 100% recommended dose; ≤50 mL/min w/ no dialysis 50% recommended dose; regular dialysis 100% recommended dose after each dialysis.