Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity & if mouth irritation occurs. Not to be used perioperatively in patients who have recently undergone CABG surgery & revascularization procedures. Exacerbation of infective inflammations eg, development of necrotising fasciitis; purulent bacterial pharyngitis/tonsillitis. History of bronchial asthma or allergic disease; HTN &/or heart failure, fluid retention & oedema; GI disease eg, ulcerative colitis, Crohn's disease, GI toxicity; serious GI events & other risk factors associated w/ PUD eg, alcoholism, smoking. Cardiac impairment; abnormal bleeding; SLE & mixed connective tissue disease; analgesic-induced headache. May cause allergic reactions due to methyl- & propyl parahydroxybenzoate. High-dose & long-term use. Avoid concomitant use w/ other NSAIDs including COX-2 selective inhibitors. Concomitant use w/ diuretics, oral corticosteroids, anticoagulants (eg, warfarin), SSRIs or antiplatelet drugs (eg, acetylsalicylic acid). Mild to moderate hepatic dysfunction. Renal impairment. May impair female fertility. Not to be given during 1st & 2nd trimesters of pregnancy. Not recommended during lactation. Childn & adolescents <18 yr. Elderly or debilitated patients.