Strepsils Max Pro have the potential for inducing transient local irritation of the buccal mucosa. The most frequently reported adverse event in clinical trials was taste perversion.
Hypersensitivity reactions have been reported and these may consist of: Nonspecific allergic reactions and anaphylaxis; respiratory tract reactivity eg, asthma, aggravated asthma, bronchospasm, dyspnoea; various skin reactions eg, pruritus, urticaria, angioedema and more rarely exfoliative and bullous dermatoses (including epidermal necrolysis and erythema multiforme).
The list of the following undesirable effects relates to those experienced with NSAIDs at doses available over-the-counter for short-term use. In the treatment of chronic conditions, under long-term treatment, additional undesirable effects may occur.
Uncommon: Urticaria and pruritus. Very Rare: Severe hypersensitivity reactions. Symptoms could be facial, tongue and laryngeal swelling, dyspnoea, tachycardia, hypotension, (anaphylaxis, angioedema or severe shock). Exacerbation of asthma and bronchospasm.
The most commonly observed adverse events are gastrointestinal in nature. Uncommon: Abdominal pain, nausea, dyspepsia. Rare: Diarrhoea, flatulence, constipation and vomiting. Very Rare: Peptic ulcer, perforation or gastrointestinal haemorrhage, melaena, haematemesis, sometimes fatal, particularly in the elderly. Ulcerative stomatitis, gastritis. Exacerbation of colitis and Crohn's disease (see Precautions).
Uncommon: Headache. Very Rare: Aseptic meningitis (single cases have been reported very rarely).
Very Rare: Acute renal failure, papillary necrosis, especially in long-term use, associated with increased serum and oedema.
Very Rare: Liver disorders.
Very Rare: Haematopoietic disorders (anaemia, leucopenia, thrombocytopenia, pancytopenia, agranulocytosis). First signs are fever, sore throat, superficial mouth ulcers, flu-like symptoms, severe exhaustion, unexplained bleeding and bruising.
Uncommon: Various skin rashes. Very Rare: Severe forms of skin reactions (bullous reactions) eg, Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis can occur.
In patients with existing autoimmune disorders (eg, systemic lupus erythematosus, mixed connective tissue disease) during treatment with ibuprofen, single cases of symptoms of aseptic meningitis eg, stiff neck, headache, nausea, vomiting, fever or disorientation have been observed (see Precautions).
Cardiovascular and Cerebrovascular:
Oedema, hypertension and cardiac failure, have been reported in association with NSAID treatment.