Sulfadimethoxine


Concise Prescribing Info
Contraindications
Severe renal or hepatic failure; blood disorders; hypersensitivity to sulfonamides; acute porphyria; SLE. Pregnancy (3rd trimester) and lactation; infants ≤2 mth.
Special Precautions
Renal or hepatic impairment; history of allergy or asthma; AIDS; G6PD deficiency; elderly; ensure adequate fluid intake to reduce risk of crystalluria. Discontinue use if rash occurs.
Adverse Reactions
Nausea, vomiting, anorexia, diarrhoea; hypersensitivity reactions, SLE, serum sickness-like syndrome, liver necrosis and hepatomegaly, myocarditis, pulmonary eosinophilia and fibrosing alveolitis, vasculitis, hypoglycaemia, hypothyroidism, neurological reactions, jaundice and kernicterus in premature neonates. Pseudomembranous colitis.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, blood dyscrasias, anaphylaxis.
Drug Interactions
Potentiates effects of oral anticoagulants, methotrexate, phenytoin. Compounds that render urine acidic increase risk of crystalluria.
Lab Interference
Interference with tests for urea, creatinine, urinary glucose, urobilinogen.
Action
Description: Sulfadimethoxine is a long-acting sulfonamide which is used in veterinary medicine, sometimes in combination with baquiloprim or ormetoprim. It was formerly used in the treatment of UTI in humans.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Sulfadimethoxine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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