Sulodexide


Concise Prescribing Info
Indications/Uses
As an antithrombotic.
Dosage/Direction for Use
Adult : PO 250 Lipoprotein lipase Releasing Units (LSU) twice daily. IV/IM Per amp contains 600 LSU: 1 amp/day for 15-20 days, then continued w/ oral form for 30-40 days. Repeat cycle at least twice a yr.
Dosage Details
Oral
Antithrombotic
Adult: 1 capsule (containing 250 LSU) bid.

Parenteral
Antithrombotic
Adult: IM/IV: 1 ampoule (containing 600 LSU) daily. Treatment may be started with parenteral form for 15-20 days, then continued with oral form for 30-40 days. Repeat treatment cycle for at least 2 times a yr.
Administration
Should be taken on an empty stomach.
Contraindications
Hypersensitivity to sulodexide, heparin, and heparin-like products. Diathesis, haemorrhagic conditions. Pregnancy.
Adverse Reactions
Oral: Nausea, vomiting, epigastric pain. Parenteral: Pain, burning and haematoma at inj site.
Action
Description: Sulodexide is a heparinoid consisting of 80% fast moving heparin and 20% dermatan sulfate. It is hypolipidaemic and antithrombotic and has been administered by mouth and parenterally for peripheral vascular disease and cerebrovascular disease. It is also included in topical preparations for local vascular inflammation and soft tissue disorders. Sulodexide differs from heparin by having a longer half-life and a decreased effect on systemic clotting and bleeding. As admin of heparin and low molecular wt heparin results in a release of lipoprotein lipase, the activity of sulodexide is expressed as Lipoprotein lipase Releasing Units (LSU). 1 mg of sulodexide is equivalent to 10 LSU.
Disclaimer: This information is independently developed by MIMS based on Sulodexide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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