Sulperazon

Sulperazon

cefoperazone + sulbactam

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Sulbactam Na, cefoperazone Na
Indications/Uses
Upper & lower resp tract infection, upper & lower UTI, peritonitis, cholecystitis, cholangitis & other intra-abdominal infections, septicemia, meningitis, skin & soft tissue infection, bone & joint infection, pelvic inflammatory disease, endometritis, gonorrhea & other genital tract infections.
Dosage/Direction for Use
IV/IM Adult 2-4 g daily in equally divided doses every 12 hr. Max daily dose: Sulbactam 4 g. Severe or refractory infections May be increased up to 8 g daily. Childn 40-80 mg/kg daily in equally divided doses every 6-12 hr. Serious or refractory infections May be increased up to 160 mg/kg daily. Neonate Max dose of sulbactam: Not to exceed 80 mg/kg daily in every 12 hr. CrCl 15-30 mL/min Sulbactam 1 g every 12 hr. Max: Sulbactam 2 g daily, <15 mL/min Sulbactam 500 mg every 12 hr. Max: Sulbactam 1 g daily.
Contraindications
Hypersensitivity to sulbactam, cefoperazone, β-lactams.
Special Precautions
Discontinue use if allergic reaction occurs. Overgrowth of non-susceptible organisms; Clostridium difficile-associated diarrhea. Vit K deficiency. Periodically check organ system dysfunction during extended therapy. Avoid alcohol consumption. Hepatic diseases &/or biliary obstruction. Pregnancy & lactation. Premature infants & neonates.
Adverse Reactions
Neutropenia, leukopenia, direct +ve Coombs' test, decreased Hb & haematocrit, thrombocytopenia; increased alanine & aspartate aminotransferase, blood alkaline phosphatase. Coagulopathy, eosinophilia; diarrhoea, nausea, vomiting; increased blood bilirubin.
MIMS Class
ATC Classification
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Sulperazon powd for inj 2 g
Packing/Price
1's
Form
Sulperazon powd for inj 1 g
Packing/Price
1's
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