Do not administer to patients with known hypersensitivity reactions. Respect usual precautions and contraindications for any intra-articular injection. Do not inject intra-vascularly. SUPLASYN should not be used in patients presenting an inflammation/irritation of the joint, since adverse events more commonly occur in patients with already existing joint inflammation/irritation. As no clinical evidence is available on the use of Hyaluronic Acid in children, pregnant and lactating women, treatment with SUPLASYN is not recommended in these patients. The patient should rest 24-48 hours after the injection and avoid any strenuous activity over the full course of the treatment.
Transient short duration pain may occur following intra-articular introduction. The affected joint may show a mild local reaction like pain, feeling of heat, hyperthermia, redness, effusion, irritation, and swelling/inflammation. If these symptoms occur, rest the affected joint and apply ice locally. Symptoms subside within days for most of the patients. In some cases, mild local reactions such as pain, irritation, swelling/joint inflammation and effusion may be significantly enhanced and much more severe as an expression of hypersensitivity. In such cases, a therapeutic intervention could be necessary, e.g. aspiration of joint fluid. Local adverse reactions could be accompanied by systemic reactions such as fever, chills, or cardiovascular reactions, and in rare cases anaphylactic reactions. In extremely rare circumstances, rash/itching, urticaria, synovitis, and a drop in blood pressure have been reported following the administration of SUPLASYN. Discontinue use if adverse reactions are experienced. Avoid using SUPLASYN with sterilising or sanitising agents containing quaternary ammonium salts solutions.