SW Metoclopramide

SW Metoclopramide





Antah Pharma
Concise Prescribing Info
Metoclopramide HCl
Symptomatic treatment of nausea & vomiting including acute migraine-induced nausea & vomiting in adults. Prevention of delayed chemotherapy-induced nausea & vomiting (CINV) & radiotherapy-induced nausea & vomiting (RINV) in adults. 2nd-line option in prevention of delayed CINV in childn 1-18 yr.
Dosage/Direction for Use
Adult Recommended single dose: 10 mg repeated up to tds. Max: 30 mg daily. Duration: 5 days. Prevention of delayed CINV Recommended dose: 0.1-0.15 mg/kg repeated up to tds. Max: 0.5 mg/kg daily. Paed 15-18 yr, >60 kg 10 mg up to tds, 9-15 yr, 30-60 kg 5 mg up to tds, 5-9 yr, 20-29 kg 2.5 mg up to tds, 3-5 yr, 15-19 kg 2 mg up to tds, 1-3 yr, 10-14 kg 1 mg up to tds. Duration: 5 days.
Should be taken on an empty stomach: Take 30 min before meals.
Hypersensitivity. GI haemorrhage, mechanical obstruction or GI perforation. Confirmed or suspected pheochromocytoma due to risk of severe HTN episodes. History of neuroleptic- or metoclopramide-induced tardive dyskinesia. Epilepsy. Parkinson's disease. Known history of methemoglobinemia w/ metoclopramide or NADH cytochrome-b5 deficiency. Combination w/ l-dopa or dopaminergic agonists. Childn <1 yr.
Special Precautions
Discontinue use if extrapyramidal symptoms, neuroleptic malignant syndrome, tardive dyskinesia, methemoglobinemia occur. Patients w/ underlying neurological disorders, cardiac conduction disorders, electrolyte imbalance, bradycardia. Parkinson's disease. High dose & long-term treatment. Concomitant use w/ other centrally-acting drugs, drugs prolonging QT interval. End-stage renal disease (CrCl ≤15 mL/min), moderate to severe renal impairment (CrCl 15-60 mL/min). Severe hepatic impairment. Pregnancy & lactation. Elderly. Tab: Not suitable for childn <30 kg.
Adverse Reactions
Restlessness, drowsiness, fatigue, lassitude.
Drug Interactions
Antagonised effect on GI motility by anticholinergics, narcotic analgesics. Additive sedative effect w/ alcohol, sedatives, hypnotics, narcotics or tranquilizers. Diminished digoxin absorption. Increased acetaminophen, tetracycline, l-dopa, ethanol, cyclosporine rate &/or extent of absorption. Concomitant use w/ MAOIs.
MIMS Class
ATC Classification
A03FA01 - metoclopramide ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
SW Metoclopramide syr 5 mg/5 mL
(banana flavour) 100 mL x 1's; (banana flavour) 120 mL x 1's; (banana flavour) 60 mL x 1's
SW Metoclopramide tab 10 mg
10 × 10's;100 × 10's;50 × 10's
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