Discontinue use if paradoxical bronchospasm occurs. Not to be initiated during exacerbation or in patients w/ significantly worsening or acutely deteriorating asthma. Allergic reactions. Cushing's syndrome, Cushingoid features, adrenal suppression, decreased bone mineral density, cataract, glaucoma, psychomotor hyperactivity, sleep disorders, anxiety, depression or aggression; periods of stress eg, severe infections, elective surgery; thyrotoxicosis, phaeochromocytoma, DM, untreated hypokalaemia, hypertrophic obstructive cardiomyopathy, idiopathic subvalvular aortic stenosis, severe HTN, aneurysm or other severe CV disorders eg, ischaemic heart disease, tachyarrhythmias or severe heart failure; QTc interval prolongation; active or quiescent pulmonary TB, fungal & viral airway infections; visual disturbances. Risk of oropharyngeal candida infection. Pneumonia in patients w/ COPD. Transferring patients from previous systemic steroid therapy. Monitor HPA axis function, serum K & blood glucose levels. Avoid abrupt w/drawal. High-dose & prolonged use. Lactose intolerance. Avoid concomitant use w/ itraconazole, ritonavir or potent CYP3A4 inhibitors. Concomitant use w/ xanthine derivatives, steroids, diuretics. Severe hepatic disease. Pregnancy & lactation. Growth retardation in childn & adolescents. Not recommended in childn <6 yr & as anti-inflammatory reliever therapy in childn <12 yr. 80/4.5 mcg: Not appropriate in patients w/ severe asthma.