History of atopy or severe anaphylactic reaction. Monitor signs of CV diseases; 1st-degree heart block; severe peripheral circulatory disturbances/disorders eg, severe forms of Raynaud's disease or Raynaud's syndrome; mild or moderate COPD; spontaneous hypoglycaemia or w/ labile diabetes; corneal diseases; angle-closure glaucoma; choroidal detachment; neovascular, narrow-angle or congenital glaucoma; aphakic patients, pigmentary or pseudoexfoliative glaucoma, pseudophakic patients w/ torn posterior lens cap or anterior chamber lenses; known risk factors for cystoid macular oedema or iritis/uveitis. Possibility of eyelash growth, darkening eyelid skin & increased iris pigmentation. Potential hair growth in skin surface areas where soln comes in contact repeatedly. May mask signs & symptoms of acute hypoglycemia, hyperthyroidism. Avoid abrupt w/drawal. Remove contact lens prior to administration & reinsert after 15 min. Not recommended w/ another topical β-blocker. Allow 5-min interval if >1 ophth drug is used. Concomitant use w/ anaesth. May affect ability to drive & use machines. Renal & hepatic impairment. Women of childbearing potential should use effective contraception. Not to be used during pregnancy. Not recommended during lactation. Not recommended in childn & adolescents <18 yr.