No specific antidote is known. In case of motor excitability or convulsions, anticonvulsive agents may be indicated. In the case of severe anaphylactic reactions, the usual counter measures are to be initiated.
Excessive serum concentrations of piperacillin/tazobactam may be reduced by hemodialysis.
The majority of overdose events experienced, including nausea, vomiting, and diarrhea, have also been reported with the usual recommended dosages. Patients may experience neuromscular excitability or convulsions if higher than recommended doses are given intravenously (particularly in the presence of renal failure).