As with other antibiotic preparations, Oxytetracycline may result in overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient for this possibility is essential. If new infections due to nonsusceptible bacteria or fungi appear during therapy, appropriate measures should be taken.
Topical application of Oxytetracycline with Polymyxin B should be supplemented with systemic administration when infections are severe or do not respond to topical therapy alone.
Usage in Children: Systemic administration of tetracyclines during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) may cause permanent discoloration of the teeth as well as retardation in the development of the skeleton. Enamel hypoplasia has also been reported. Although these effects are unlikely following topical application of tetracyclines because of the low doses used, the possibility that these effects could occur should be considered.
Effects on ability to drive and use machines: Oxytetracycline topical preparations are not expected to have an influence on the ability to drive and to operate machinery. However, directly following the application of the ophthalmic dosage form, a short period of less acute vision may occur.