Pregnancy: There are no controlled studies to date using topical tetracyclines in pregnant women. The use of systemic tetracyclines in pregnant women has resulted in retardation of skeletal development and bone growth in the fetus. None the less, topical tetracyclines should be used during pregnancy only when the possible benefits outweigh the potential risks.
Lactation: It is not known whether topically applied tetracyclines are distributed into breast milk. Tetracyclines are distributed into milk following systemic administration. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.