Thiomersal


Concise Prescribing Info
Indications/Uses
As an antiseptic agent.
Dosage/Direction for Use
Adult : Topical As 0.1% soln: Apply as directed.
Dosage Details
Topical/Cutaneous
Antiseptic agent
Adult: To be applied topically usually in a concentration of 0.1%.
Incompatibility
Incompatible with acids, metal ions and iodine. It forms precipitates with many alkaloids and may be adsorbed by plastic or rubber packaging materials. Activity of thiomersal may be reduced by boric acid, edetic acid or sodium thiosulfate or by the presence of blood or organic matter.
Contraindications
Hypersensitivity.
Special Precautions
May cause serious mercury poisoning on frequent or long-term use or application to large areas.
Adverse Reactions
Hypersensitivity.
Overdosage
As per mercury poisoning, gastritis, renal failure, dermatitis, gingivitis, delirium, polyneuropathy, respiratory failure and coma. Activated charcoal, chelating drugs or gastric lavage to reduce absorption. Treatment is symptomatic.
Drug Interactions
Ocular irritation of varying degrees occurs after concomitant admin of contact lens soln containing 0.004% and oral tetracyclines.
Action
Description: Thiomersal is a bacteriostatic and fungistatic mercurial antiseptic that is often used topically. Its antibacterial action results from the release of ethylmercury after breakdown to thiosalicylate and ethylmercury. It is often used as a preservative in biological and pharmaceutical products, as well as contact lens solutions in the concentration between 0.001 to 0.01%.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Thiomersal from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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