Thyrogen

Thyrogen Drug Interactions

thyrotropin alfa

Manufacturer:

Genzyme

Distributor:

DKSH
Full Prescribing Info
Drug Interactions
Drug/Drug: Formal interaction studies between Thyrogen and other medicinal products have not been performed. In clinical trials, no interactions were observed between Thyrogen and the thyroid hormones, triiodothyronine (T3) and thyroxine (T4), when administered concurrently.
The use of Thyrogen allows for radioiodine imaging while patients are euthyroid on T3 and/or T4. Data on radioiodine kinetics indicate that the clearance of radioiodine is approximately 50% greater while euthyroid than during the hypothyroid state when renal function is decreased, thus resulting in less radioiodine retention in the body at the time of imaging. This factor should be considered when selecting the activity of radioiodine for use in radioiodine imaging.
Drug/Food: None known.
Pharmaceutical Incompatibilities: None known. Injection material should not be mixed with other substances.
Drug/Laboratory Tests: In clinical trials, the reference standard for determining whether patients had thyroid remnant or cancer present was a hypothyroid Tg ≥ 2.0 ng/mL and/or a hypothyroid scan (either diagnostic or post-therapy).
This analysis evaluated whether Tg testing after Thyrogen administration improved the diagnostic sensitivity of a Tg test in patients with a negative Tg on thyroid hormone suppression therapy (THST) using a cut-off of 2.0 ng/mL. It should be noted that Thyrogen-Tg levels are generally lower than hypothyroid-Tg levels and thus physicians may need to use a lower Tg cut-off level when using Thyrogen than would be used with a hypothyroid-Tg.
The use of Thyrogen allows for radioiodine imaging while patients are euthyroid on T3 and/or T4. Data on radioiodine kinetics indicate that the clearance of radioiodine is approximately 50% greater while euthyroid than during the hypothyroid state, thus resulting in less radioiodine retention in the body at the time of imaging. This difference in radioiodine clearance is caused by decreased renal function in the hypothyroid state. This factor should be considered when selecting the activity of radioiodine for use in radioiodine imaging.
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