Tianeptine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Depression

Adult: 12.5 mg tid.
Elderly: Dose reduction to total daily dose of 25 mg.

Renal Impairment

Reduce total daily dose to 25 mg/day.

Administration

Should be taken on an empty stomach. Take before main meals.

Contraindications

Childn <15 yrs. Pregnancy and lactation.

Special Precautions

General anaesthesia; tasks requiring mental alertness. Avoid abrupt withdrawal, dosage to be decreased gradually over 7-14 days.

Adverse Reactions

Abdominal pain, fatigue, nausea, constipation, lack of appetite, insomnia, drowsiness, palpitations, muscular or joint pain, headache, vertigo, tremour, dry mouth, hepatitis (rare)

Overdosage

Gastric lavage followed by symptomatic treatment and monitoring of CV, respiratory, metabolic and renal function.

Drug Interactions

Potentially Fatal: Avoid concurrent admin with MAOI, start tianeptine 2 wk after discontinuation from MAOI.

Food Interaction

Decreased absorption with alcohol.

Action

Description: Tianeptine exerts its antidepressant action by increasing the presynaptic re-uptake of serotonin.

Storage

Store below 30°C.

MIMS Class

Antidepressants

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