Discontinue use if venous thromboembolism develops & in case of jaundice or hepatic function deterioration, significant BP increase, new onset of migraine-type headache. Not intended for contraceptive use. Increased risk of ischaemic stroke, breast, ovarian & endometrial cancer. Exclude endometrial malignancy prior to therapy; breakthrough bleeding & spotting. Leiomyoma or endometriosis; history of or risk factors for thromboembolic disorders & estrogen-dependent tumors; HTN; DM w/ or w/o vascular involvement; cholelithiasis; migraine or headache; SLE; history of endometrial hyperplasia; epilepsy; asthma; otosclerosis. Preexisting hypertriglyceridemia; cardiac dysfunction. Women on anticoagulant treatment. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Hepatic disorders. Renal dysfunction.