Dosage in Adult: The usual daily adult dosage of clindamycin phosphate for infections of the intraabdominal area, female pelvis and other complicated or serious infections is 2400-2700 mg given in 2, 3, or 4 equal doses. Less complicated infections due to more susceptible microorganisms may respond to lower doses such as 1200-1800 mg/day administered in 3 or 4 equal doses.
Doses of up to 4800 mg daily have been used successfully.
Single IM doses of greater than 600 mg are not recommended.
Dosage in Children (over 1 month of age): 20-40 mg/kg/day in 3 or 4 equal doses.
Dosage in Neonates (under 1 month of age): 15-20 mg/kg/day in 3 or 4 equal doses. The lower dosage may be adequate for small premature infants.
Dosage in Elderly: Pharmacokinetic studies with clindamycin have shown no clinical important differences between young and elderly subjects with normal hepatic function and normal (age-adjusted) renal function after oral or intravenous administration. Therefore, dosage adjustments are not necessary in the elderly with normal hepatic function and normal (age-adjusted) renal function.
Dosage in Renal Impairment: Clindamycin dosage modification is not necessary in patients with renal insufficiency.
Dosage in Hepatic Impairment: Clindamycin dosage modification is not necessary in patients with hepatic insufficiency.
Dosage in Specific Indication: Treatment of Beta-Hemolytic Streptococcal Infections: Treatment should be continued for at least 10 days.
Inpatient treatment of Pelvic Inflammatory Disease: Clindamycin Phosphate 900mg (IV) every 8 hours daily plus an antibiotic with an appropriate gram negative aerobic spectrum administered IV, e.g., gentamicin 2.0 mg/kg followed by 1.5 mg/kg every 8 hours daily in patients with normal renal function. Continue (IV) drugs for at least 4 days and at least 48 hours after patient improves. Then continue oral clindamycin hydrochloride treatment.
Treatment of Toxoplasmic Encephalitis in patients with AIDS: Clindamycin Phosphate IV or clindamycin hydrochloride orally 600-1200 mg every 6 hours for 2 weeks followed by 300-600 mg orally every 6 hours. The usual total duration of therapy is 8 to 10 weeks. The dose of pyrimethamine is 25 to 75 mg orally each day for 8 to 10 weeks. Folinic acid 10 to 20 mg/day should be given with higher doses of pyrimethamine.
Treatment of Pneumocystis jiroveci (previously classified as Pneumocystis carinii) Pneumonia in patient with AIDS: Clindamycin phosphate IV 600 to 900 mg every 6 hours or 900 mg IV every 8 hours or clindamycin hydrochloride 300 to 450 mg orally every 6 hours for 21 days and Primaquine 15 to 30 mg dose orally once daily for 21 days.
Mode of Administration: IM or IV.