Open-angle glaucoma, Ocular hypertension
Adult: Eye drop soln: Initially, instill 1 drop of 0.25% soln bid into the affected eye(s), may increase to 1 drop of 0.5% soln bid if there is inadequate response; decrease to 1 drop once daily if controlled. Do not exceed 1 drop bid of 0.5% soln. As 0.25% or 0.5% gel-forming eye drops: Instill 1 drop into the affected eye(s) once daily.
Adult: Initially, 5 mg bid for 2 days, starting w/in 1-4 wk after MI, increased to 10 mg bid if no adverse effects are observed.
Adult: Initially, 10 mg/day, increased according to response every 7 or more days. Maintenance: 10-40 mg/day. Max: 60 mg/day. Doses >30 mg/day should be given in 2 divided doses.
Prophylaxis of migraine
Adult: 10 mg once daily or bid. Max: 30 mg/day in divided doses.
Adult: Initially, 5 mg bid, increased by 10 mg/day every 3 or more days. Usual: 35-45 mg/day in divided doses. Max: 60 mg/day.