Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration
Adult: Short-term dialysis (≤4 hr): 2,000-2,500 U as a single dose. Long-term dialysis (>4 hr): Initially, 2,500 U followed by an infusion of 750 U/hr. Dose may also be given into the arterial side of the dialyser. The dialyser can be primed w/ 500-1,000 mL NaCl 0.9% containing 5,000 U tinzaparin Na/L.
Prophylaxis of postoperative venous thromboembolism
Adult: Low or intermediate risk patients: 3,500 U given 2 hr before surgery, followed by 3,500 U once daily. High risk patients: Initially, 50 U/kg given 2 hr before surgery, or a fixed dose of 4,500 U given 12 hr before surgery followed by a once daily dose; alternatively, 75 U/kg once daily, started after surgery.
Adult: 175 U/kg once daily for at least 6 days and until adequate oral anticoagulation is established. Pregnant patients: Early-pregnancy body wt should be used to calculate dose.