Prophylaxis of clotting in the extracorporeal circulation during haemodialysis
Adult: Dialysis session ≤4 hours: 2,000-2,500 international units given as bolus dose at the start of dialysis. Dialysis session >4 hours: 2,500 international units given as bolus dose at the start of dialysis, followed by continuous infusion of 750 international units/hour. Dose may be adjusted gradually in increments of 500 international units according to response. Dose may be given into the arterial side of the dialyser or via IV inj. The dialyser may be primed by flushing with 500-1,000 mL NaCl 0.9% containing 5,000 international units tinzaparin/L.
Prophylaxis of venous thromboembolism
Adult: Surgical patients at moderate risk: 3,500 international units given 2 hours before surgery, then once daily. Surgical patients at high risk (e.g. undergoing orthopaedic or cancer surgery): 4,500 international units given 12 hours before surgery, then once daily. Non-surgical patients immobilised due to acute medical illness (e.g. heart failure, respiratory failure, severe infections, active cancer): 3,500 international units once daily for patients at moderate risk; 4,500 international units once daily for patients at high risk. Continue doses for as long as the patient remains at risk of VTE.
Adult: For the treatment of DVT and/or pulmonary embolism: 175 international units/kg once daily for at least 6 days and until adequate oral anticoagulation is established. Extended treatment and prevention of recurrence in patients with active cancer: 175 international units/kg once daily for 6 months.